Liverpool vs. Real Madrid prediction, odds, betting tips and best bets ...

Experiencing a run of sensational form through the first few months of Arne Slot's time in charge, Liverpool face their toughest test yet as they host defending European champions Real Madrid in the Champions League on Wednesday.

The Reds currently sit atop both the Premier League and Champions League standings as December nears, an absolutely unfathomable achievement when Slot took over from the beloved Jurgen Klopp this summer. They have won all four of their European games thus far and hold an eight-point lead atop the English top flight table.

While Real Madrid have experienced significantly more adversity this season, sitting 18th in the Champions League table, they still present formidable opposition. Yet Los Blancos are down a number of key players due to injury, with Eder Militao and Dani Carvajal lost for the season and both Brazilian attacking stars Vinicius Jr and Rodrygo sidelined for the near future.

If Slot can hold serve at home, the sky is the limit for Liverpool this season on multiple fronts.

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Liverpool vs. Real Madrid prediction, oddsMoneyline lean: Liverpool (-110 on BetMGM)Score prediction: Liverpool 3-1 Real Madrid

While Real Madrid prove a threat no matter their form or situation, it's just too difficult to back Los Blancos on the road against this kind of in-form opponent with so many injuries to work through. The Spanish giants have already struggled to push through their defensive absences, and now Vinicius Jr's injury may be too much to overcome.

Kylian Mbappe may enjoy the benefits of having the Real Madrid attack to himself, but the rest of the squad will struggle to adapt. On the road at Anfield, this is too good an opportunity for Liverpool to pass up.

 BetMGM
(USA)Liverpool win-110Draw+280Real Madrid win+270Both teams
to scoreY: -210
N: +140Over / Under
3.5 goalsO: +120
U: -175Liverpool
-0.5 goals-120Real Madrid
+0.5 goals-115Liverpool vs. Real Madrid match factsDate: Wednesday, November 27, 2024Kickoff Time: 8 p.m. local (3 p.m. ET / 12 p.m. PT)Location: Anfield Stadium (Liverpool, England)Referee: Francois Letexier (FRA)Last meeting: Real Madrid 1-0 Liverpool (Mar. 15, 2023 | Champions League)Liverpool vs. Real Madrid best betPick: Mohamed Salah to score or assist a goalOdds: -130 on FanDuelPick: Mohamed Salah to score AND assist a goalOdds: +530 on FanDuel

There's nobody in better form throughout all of Europe than Mohamed Salah. Regardless of location, opponent, or situation, the Egyptian has been able to either find the net himself or tee up a teammate for a high-percentage opportunity.

Salah has either scored or assisted a goal in 13 of 16 matches this season across the Premier League and Champions League, and has registered one of each in five of them. Given Real Madrid's injury woes, plus the awful form of Ferland Mendy (whom Carlo Ancelotti said will get another look against Liverpool, gulp) on Salah's side, this is an exceptional opportunity for the Egyptian to pick up his first-ever win against Real Madrid on his ninth try.

Liverpool vs. Real Madrid prop betPick: Kylian Mbappe to score or assist a goalOdds: +130 on FanDuel

Plus odds for a Kylian Mbappe masterclass in a losing effort is a gift.

The French superstar has struggled to adapt himself to a front line that includes other winger-y forwards Vinicius Jr. and Rodrygo. Now, with both of those Brazilian teammates sidelined due to injury, the attack will lean heavily on Mbappe, a situation in which he thrives.

With a goal on five attempts against Leganes over the weekend, Mbappe is now potentially finding his footing at Madrid, and his influence will be key if the Spanish visitors are to have any attacking joy against an in-form Liverpool back line. He's familiar with such a result, having scored in a 3-2 defeat at Anfield for PSG way back in 2018.